Dr Simon Babayan
Location: Room 4.02, Ashworth Laboratories
Phone: +44131 650 8682
Email: s.babayan@ed.ac.uk
Positions
Publications
Forthcoming
1. Babayan S. A., Taylor D. W., Allen J. E. Future prospects & challenges of vaccines against filariasis. (Invited review, Para. Immunol.)
2. Babayan S. A., Luo H. L., Gray N., Taylor D. W., Allen J. E. A vaccine strategy that combines inactivated parasite immune modulators with host immune enhancers successfully protects against filarial infection. Submitted.
3. Luo H. L., Gray N., Taylor D. W., Allen J. E., Babayan S. A. Enhancing parasite antigen immunogenicity with concomitant targeting of parasite-driven immune suppression. In Prep.
4. Babayan S. A., Coltherd J. C., Gray N., Bünger, L., Houdijk J., Allen J. E. Protein scarcity alters immunity to gut nematode infection. In Prep.
In Press and Published
1. Little T. J., Allen J. E., Babayan S. A., Matthews K. R. and Colegrave N. Harnessing evolutionary biology to combat infectious disease. (In Press, Nat. Immunol.)
2. Babayan, S. A., Allen, J. E., Bradley, J. E., Geuking, M. B., Graham, A. L., Grencis, R. K., Kaufman, J., McCoy, K. D., Paterson, S., Smith, K. G., Turnbaugh, P. J., Viney, M. E., Maizels, R. M., & Pedersen, A. B. (2011). Ann N Y Acad Sci, 1236(1), 17-29. doi:10.1111/j.1749-6632.2011.06251.x
3. Coltherd J. C., Babayan S. A., Bünger L., Kyriazakis I., Allen J. E., Houdijk J. G. M. (2011). Interactive effects of protein nutrition, genetic growth potential, and Heligmosomoides bakeri infection pressure on resilience, resistance and serum antibodies in mice. Parasitology 138, 1305-1315.
4. Pedersen A. B. and Babayan S. A. (2011). Wild Immunology. Mol Ecol 20: 872-880.
5. Babayan S. A., Read A. F., Lawrence R. A., Bain O., Allen J. E. (2010). Filarial Parasites Develop Faster and Reproduce Earlier in Response to Host Immune Effectors Which Determine Filarial Life Expectancy. PloS Biology, 8(10): e1000525
6. Coltherd J. C., Babayan S. A., Bunger L., Kyriazakis I., Allen J. E. and Houdijk J. G. M.(2009). Immune responses to macroparasites are sensitive to the interaction between genetic growth potential and protein nutrition in mice. Proceedings of the Nutrition Society, 68 (OCE), E101 [Not peer-reviewed].
7. Attout T., Martin C., Babayan S.A., Kozek W.J., Bazzocchi C., Oudet F., Gallagher I.J., Specht S., and Bain O. (2008). Pleural cellular reaction to the filarial infection Litomosoides sigmodontis is determined by the moulting process, the worm alteration, and the host strain. Parasitology international. 57, 201-211.
8. Houston K.M., Babayan S.A., Allen J.E., and Harnett W. (2008). Does Litomosoides sigmodontis synthesize dimethylethanolamine from choline? Parasitology. 135, 55-61.
9. Taylor M.D., Harris A., Babayan S.A., Bain O., Culshaw A., Allen J.E., and Maizels R.M. (2007). CTLA-4 and CD4+CD25+ Regulatory T Cells Inhibit Protective Immunity to Filarial Parasites In Vivo. J Immunol. 179, 4626-4634.
10. Babayan S.A., Attout T., Harris A., Taylor M.D., Le Goff L., Vuong P.N., Renia L., Allen J.E., and Bain O. (2006). Vaccination against filarial nematodes with irradiated larvae provides long-term protection against the third larval stage but not against subsequent life cycle stages. Int J Parasitol. 36, 903-914.
11. Babayan S.A., Attout T., Vuong P.N., Le Goff L., Gantier J.C., and Bain O. (2005). The subcutaneous movements of filarial infective larvae are impaired in vaccinated hosts in comparison to primary infected hosts. Filaria J. 4, 3.
12. Attout T., Babayan S., Hoerauf A., Taylor D., Kozek W., Martin C., and Bain O. (2005). Blood-feeding in the young adult filarial worms Litomosoides sigmodontis. Parasitology. 130, 421-428.
13. Babayan S., Attout T., Specht S., Hoerauf A., Snounou G., Renia L., Korenaga M., Bain O., and Martin C. (2005). Increased early local immune responses and altered worm development in high-dose infections of mice susceptible to the filaria Litomosoides sigmodontis. Med Microbiol Immunol (Berl). 194, 151-162.
14. Babayan S., Ungeheuer M., Martin C., Attout T., Belnoue E., Snounou G., Renia L., Korenaga M., and Bain O. (2003). Resistance and susceptibility to filarial infection with Litomosoides sigmodontis are associated with early differences in parasite development and in localized immune reactions. Infection and Immunity. 71, 6820-6829.
15. Bain O., Guerrero R., Rodriguez B., Babayan S., and Jouvenet N. (2003). Examination of type material of two species of Litomosoides (Filarioidea: Onchocercidae), parasites from bats; taxonomic consequences. Parasite. 10, 211-8.
16. Bain O., and Babayan S. (2003). Behaviour of filariae: morphological and anatomical signatures of their life style within the arthropod and vertebrate hosts. Filaria J. 2, 16.
17. Bain O., Babayan S., Gomes J., Rojas G., and Guerrero R. (2002). First account on the larval biology of a Litomosoides filaria, from a bat. Parassitologia. 44, 89-92.
18. Martin C., Saeftel M., Vuong P.N., Babayan S., Fischer K., Bain O., and Hoerauf A. (2001). B-cell deficiency suppresses vaccine-induced protection against murine filariasis but does not increase the recovery rate for primary infection. Infection and Immunity. 69, 7067-7073.
- Current: Co-PI on European FP7 grant on Enhancing Protective Immunity Against Filariasis (EPIAF), University of Edinburgh, UK
- Research Fellow, Wellcome Trust Centre for Immunity, Infection & Evolution (CIIE), University of Edinburgh, UK
- Marie-Curie Fellow, Institute of Immunology and Infection Research (IIIR), University of Edinburgh, UK
- PhD at the Museum National d’Histoire Naturelle, Paris, France.
Publications
Forthcoming
1. Babayan S. A., Taylor D. W., Allen J. E. Future prospects & challenges of vaccines against filariasis. (Invited review, Para. Immunol.)
2. Babayan S. A., Luo H. L., Gray N., Taylor D. W., Allen J. E. A vaccine strategy that combines inactivated parasite immune modulators with host immune enhancers successfully protects against filarial infection. Submitted.
3. Luo H. L., Gray N., Taylor D. W., Allen J. E., Babayan S. A. Enhancing parasite antigen immunogenicity with concomitant targeting of parasite-driven immune suppression. In Prep.
4. Babayan S. A., Coltherd J. C., Gray N., Bünger, L., Houdijk J., Allen J. E. Protein scarcity alters immunity to gut nematode infection. In Prep.
In Press and Published
1. Little T. J., Allen J. E., Babayan S. A., Matthews K. R. and Colegrave N. Harnessing evolutionary biology to combat infectious disease. (In Press, Nat. Immunol.)
2. Babayan, S. A., Allen, J. E., Bradley, J. E., Geuking, M. B., Graham, A. L., Grencis, R. K., Kaufman, J., McCoy, K. D., Paterson, S., Smith, K. G., Turnbaugh, P. J., Viney, M. E., Maizels, R. M., & Pedersen, A. B. (2011). Ann N Y Acad Sci, 1236(1), 17-29. doi:10.1111/j.1749-6632.2011.06251.x
3. Coltherd J. C., Babayan S. A., Bünger L., Kyriazakis I., Allen J. E., Houdijk J. G. M. (2011). Interactive effects of protein nutrition, genetic growth potential, and Heligmosomoides bakeri infection pressure on resilience, resistance and serum antibodies in mice. Parasitology 138, 1305-1315.
4. Pedersen A. B. and Babayan S. A. (2011). Wild Immunology. Mol Ecol 20: 872-880.
5. Babayan S. A., Read A. F., Lawrence R. A., Bain O., Allen J. E. (2010). Filarial Parasites Develop Faster and Reproduce Earlier in Response to Host Immune Effectors Which Determine Filarial Life Expectancy. PloS Biology, 8(10): e1000525
6. Coltherd J. C., Babayan S. A., Bunger L., Kyriazakis I., Allen J. E. and Houdijk J. G. M.(2009). Immune responses to macroparasites are sensitive to the interaction between genetic growth potential and protein nutrition in mice. Proceedings of the Nutrition Society, 68 (OCE), E101 [Not peer-reviewed].
7. Attout T., Martin C., Babayan S.A., Kozek W.J., Bazzocchi C., Oudet F., Gallagher I.J., Specht S., and Bain O. (2008). Pleural cellular reaction to the filarial infection Litomosoides sigmodontis is determined by the moulting process, the worm alteration, and the host strain. Parasitology international. 57, 201-211.
8. Houston K.M., Babayan S.A., Allen J.E., and Harnett W. (2008). Does Litomosoides sigmodontis synthesize dimethylethanolamine from choline? Parasitology. 135, 55-61.
9. Taylor M.D., Harris A., Babayan S.A., Bain O., Culshaw A., Allen J.E., and Maizels R.M. (2007). CTLA-4 and CD4+CD25+ Regulatory T Cells Inhibit Protective Immunity to Filarial Parasites In Vivo. J Immunol. 179, 4626-4634.
10. Babayan S.A., Attout T., Harris A., Taylor M.D., Le Goff L., Vuong P.N., Renia L., Allen J.E., and Bain O. (2006). Vaccination against filarial nematodes with irradiated larvae provides long-term protection against the third larval stage but not against subsequent life cycle stages. Int J Parasitol. 36, 903-914.
11. Babayan S.A., Attout T., Vuong P.N., Le Goff L., Gantier J.C., and Bain O. (2005). The subcutaneous movements of filarial infective larvae are impaired in vaccinated hosts in comparison to primary infected hosts. Filaria J. 4, 3.
12. Attout T., Babayan S., Hoerauf A., Taylor D., Kozek W., Martin C., and Bain O. (2005). Blood-feeding in the young adult filarial worms Litomosoides sigmodontis. Parasitology. 130, 421-428.
13. Babayan S., Attout T., Specht S., Hoerauf A., Snounou G., Renia L., Korenaga M., Bain O., and Martin C. (2005). Increased early local immune responses and altered worm development in high-dose infections of mice susceptible to the filaria Litomosoides sigmodontis. Med Microbiol Immunol (Berl). 194, 151-162.
14. Babayan S., Ungeheuer M., Martin C., Attout T., Belnoue E., Snounou G., Renia L., Korenaga M., and Bain O. (2003). Resistance and susceptibility to filarial infection with Litomosoides sigmodontis are associated with early differences in parasite development and in localized immune reactions. Infection and Immunity. 71, 6820-6829.
15. Bain O., Guerrero R., Rodriguez B., Babayan S., and Jouvenet N. (2003). Examination of type material of two species of Litomosoides (Filarioidea: Onchocercidae), parasites from bats; taxonomic consequences. Parasite. 10, 211-8.
16. Bain O., and Babayan S. (2003). Behaviour of filariae: morphological and anatomical signatures of their life style within the arthropod and vertebrate hosts. Filaria J. 2, 16.
17. Bain O., Babayan S., Gomes J., Rojas G., and Guerrero R. (2002). First account on the larval biology of a Litomosoides filaria, from a bat. Parassitologia. 44, 89-92.
18. Martin C., Saeftel M., Vuong P.N., Babayan S., Fischer K., Bain O., and Hoerauf A. (2001). B-cell deficiency suppresses vaccine-induced protection against murine filariasis but does not increase the recovery rate for primary infection. Infection and Immunity. 69, 7067-7073.